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Richter transformation continues to be an ominous event for sufferers with CLL, especially when it is actually clonally connected to the first CLL, simply because none of the a short while ago accredited novel brokers is really efficient. Without a doubt, disorder transformation is a comparatively common cause of failure to get pleasure from these drugs.90,128,129 Histological confirmation is often encouraged as it can guidebook prognosis (i.e., Hodgkin lymphoma and clonally unrelated tumors have more favorable prognosis).
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